| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Cape Coral | 1 | 245,680 | 195,442 | 3.99% | 2,315 | 106 | City |
| Fort Myers | 2 | 104,797 | 87,289 | 3.17% | 2,614 | 40 | City |
| Bonita Springs | 3 | 58,458 | 53,894 | 1.43% | 1,522 | 38 | City |
| Estero | 4 | 38,718 | 37,044 | 0.92% | 1,589 | 24 | Village |
| Sanibel | 5 | 6,300 | 6,388 | -0.05% | 389 | 16 | City |
| Fort Myers Beach | 6 | 5,219 | 5,584 | -1.29% | 1,876 | 3 | Town |
Cape Coral is the largest city in Lee County, with a population of 245,680.
Fort Myers Beach is the smallest city in Lee County, with a population of 5,219.
There are 6 cities in Lee County, Florida.