Sanibel
- County:
- Lee County
- County Seat:
- No
- Area (mi²):
- 16.18
- State:
- Florida
Sanibel is a city located in Lee County, Florida. Sanibel has a 2026 population of 6,358. Sanibel is currently declining at a rate of -0.81% annually and its population has decreased by -0.49% since the most recent census, which recorded a population of 6,389 in 2020.