29 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Carbondale | 1 | 25,287 | 25,019 | 0.58% | 676 | 37 | Township |
| Carbondale | 2 | 22,203 | 22,263 | -0.05% | 1,270 | 17 | City |
| Murphysboro | 3 | 9,542 | 9,451 | 0.63% | 263 | 36 | Township |
| Murphysboro | 4 | 7,027 | 7,078 | -0.11% | 1,339 | 5 | City |
| Makanda | 5 | 4,102 | 4,043 | 0.71% | 111 | 37 | Township |
| Somerset | 6 | 4,031 | 3,984 | 0.62% | 109 | 37 | Township |
| De Soto | 7 | 2,326 | 2,290 | 0.74% | 64 | 36 | Township |
| Elk | 8 | 1,766 | 1,741 | 0.68% | 49 | 36 | Township |
| Crainville | 9 | 1,517 | 1,444 | 0.8% | 918 | 2 | Village |
| De Soto | 10 | 1,408 | 1,408 | 0% | 1,544 | 1 | Village |
| Levan | 11 | 847 | 839 | 0.47% | 25 | 33 | Township |
| Elkville | 12 | 833 | 836 | 0% | 1,086 | 1 | Village |
| Pomona | 13 | 796 | 782 | 0.76% | 16 | 50 | Township |
| Sand Ridge | 14 | 695 | 677 | 0.87% | 20 | 35 | Township |
| Vergennes | 15 | 683 | 676 | 0.74% | 19 | 37 | Township |
| Grand Tower | 16 | 567 | 561 | 0.71% | 18 | 32 | Township |
| Ava | 17 | 546 | 549 | 0% | 517 | 1 | City |
| Makanda | 18 | 539 | 539 | 0% | 102 | 5 | Village |
| Ora | 19 | 515 | 509 | 0.78% | 14 | 37 | Township |
| Grand Tower | 20 | 474 | 477 | 0% | 380 | 1 | City |
| Kinkaid | 21 | 451 | 453 | 0.22% | 13 | 36 | Township |
| Dowell | 22 | 367 | 366 | 0% | 941 | 0 | Village |
| Campbell Hill | 23 | 306 | 311 | -0.33% | 662 | 0 | Village |
| Vergennes | 24 | 237 | 234 | 0.42% | 673 | 0 | Village |
| Bush | 25 | 235 | 241 | -0.42% | 516 | 0 | Village |
| Fountain Bluff | 26 | 191 | 193 | 0% | 6 | 30 | Township |
| Gorham | 27 | 171 | 171 | 0% | 140 | 1 | Village |
| St. Johns | 28 | 154 | 162 | -0.65% | 212 | 1 | Village |
| Degognia | 29 | 149 | 147 | 0.68% | 5 | 30 | Township |
Carbondale is the largest city in Jackson County, with a population of 25,287.
Degognia is the smallest city in Jackson County, with a population of 149.
There are 29 cities in Jackson County, Illinois.