6 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Du Quoin | 1 | 5,610 | 5,819 | -0.74% | 804 | 6.98 | City |
| Pinckneyville | 2 | 4,952 | 5,059 | -0.42% | 1,206 | 4.11 | City |
| Willisville | 3 | 561 | 578 | -0.53% | 1,442 | 0.39 | Village |
| Tamaroa | 4 | 527 | 541 | -0.57% | 550 | 0.96 | Village |
| Cutler | 5 | 348 | 360 | -0.57% | 744 | 0.47 | Village |
| New Minden | 6 | 165 | 167 | 0% | 596 | 0.28 | Village |
Du Quoin is the largest city in Perry County, with a population of 5,610.
New Minden is the smallest city in Perry County.
There are 6 cities in Perry County, Illinois.