6 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Du Quoin | 1 | 5,511 | 5,811 | -0.9% | 790 | 7 | City |
| Pinckneyville | 2 | 4,912 | 5,065 | -0.51% | 1,196 | 4 | City |
| Willisville | 3 | 550 | 577 | -0.72% | 1,414 | 0 | Village |
| Tamaroa | 4 | 519 | 542 | -0.76% | 542 | 1 | Village |
| Cutler | 5 | 349 | 366 | -0.85% | 746 | 0 | Village |
| New Minden | 6 | 161 | 166 | -0.62% | 581 | 0 | Village |
Du Quoin is the largest city in Perry County, with a population of 5,511.
New Minden is the smallest city in Perry County, with a population of 161.
There are 6 cities in Perry County, Illinois.