6 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Du Quoin | 1 | 5,561 | 5,811 | -0.89% | 797 | 7 | City |
| Pinckneyville | 2 | 4,937 | 5,065 | -0.52% | 1,202 | 4 | City |
| Willisville | 3 | 554 | 577 | -0.89% | 1,424 | 0 | Village |
| Tamaroa | 4 | 523 | 542 | -0.76% | 546 | 1 | Village |
| Cutler | 5 | 352 | 366 | -0.85% | 752 | 0 | Village |
| New Minden | 6 | 162 | 166 | -0.61% | 585 | 0 | Village |
Du Quoin is the largest city in Perry County, with a population of 5,561.
New Minden is the smallest city in Perry County, with a population of 162.
There are 6 cities in Perry County, Illinois.