| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Du Quoin | 1 | 5,525 | 5,785 | -0.79% | 792 | 7 | City |
| Pinckneyville | 2 | 4,891 | 5,063 | -0.24% | 1,191 | 4 | City |
| Willisville | 3 | 556 | 577 | -0.71% | 1,429 | 0 | Village |
| Tamaroa | 4 | 520 | 542 | -0.76% | 543 | 1 | Village |
| Cutler | 5 | 348 | 364 | -0.85% | 744 | 0 | Village |
| New Minden | 6 | 165 | 167 | -0.6% | 596 | 0 | Village |
Du Quoin is the largest city in Perry County, with a population of 5,525.
New Minden is the smallest city in Perry County, with a population of 165.
There are 6 cities in Perry County, Illinois.