| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Clinton | 1 | 6,751 | 6,973 | -0.44% | 1,905 | 4 | City |
| Farmer City | 2 | 1,792 | 1,826 | -0.28% | 748 | 2 | City |
| McLean | 3 | 730 | 744 | -0.41% | 620 | 1 | Village |
| Wapella | 4 | 494 | 511 | -0.6% | 897 | 1 | Village |
| Waynesville | 5 | 368 | 377 | -0.27% | 1,154 | 0 | Village |
| Weldon | 6 | 354 | 362 | -0.28% | 1,326 | 0 | Village |
| Kenney | 7 | 296 | 298 | -0.34% | 1,050 | 0 | Village |
| De Witt | 8 | 160 | 160 | 0% | 675 | 0 | Village |
Clinton is the largest city in De Witt County, with a population of 6,751.
De Witt is the smallest city in De Witt County, with a population of 160.
There are 8 cities in De Witt County, Illinois.