| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Fairfield | 1 | 4,769 | 4,890 | -0.52% | 1,164 | 4 | City |
| Wayne City | 2 | 982 | 999 | -0.41% | 568 | 2 | Village |
| Cisne | 3 | 609 | 620 | -0.49% | 967 | 1 | Village |
| Jeffersonville | 4 | 347 | 355 | -0.57% | 343 | 1 | Village |
| Sims | 5 | 163 | 166 | -0.61% | 138 | 1 | Village |
| Mount Erie | 6 | 95 | 98 | -1.04% | 247 | 0 | Village |
| Johnsonville | 7 | 79 | 82 | -1.25% | 371 | 0 | Village |
| Golden Gate | 8 | 60 | 62 | -1.64% | 759 | 0 | Village |
| Keenes | 9 | 47 | 48 | -2.08% | 362 | 0 | Village |
Fairfield is the largest city in Wayne County, with a population of 4,769.
Keenes is the smallest city in Wayne County, with a population of 47.
There are 9 cities in Wayne County, Illinois.