9 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Fairfield | 1 | 4,741 | 4,887 | -0.5% | 1,157 | 4 | City |
| Wayne City | 2 | 986 | 1,004 | -0.3% | 570 | 2 | Village |
| Cisne | 3 | 619 | 628 | -0.16% | 983 | 1 | Village |
| Jeffersonville | 4 | 347 | 355 | -0.29% | 343 | 1 | Village |
| Sims | 5 | 168 | 170 | 0% | 142 | 1 | Village |
| Mount Erie | 6 | 94 | 97 | 0% | 245 | 0 | Village |
| Johnsonville | 7 | 70 | 72 | 0% | 329 | 0 | Village |
| Golden Gate | 8 | 61 | 63 | 0% | 772 | 0 | Village |
| Keenes | 9 | 49 | 48 | 0% | 377 | 0 | Village |
Fairfield is the largest city in Wayne County, with a population of 4,741.
Keenes is the smallest city in Wayne County, with a population of 49.
There are 9 cities in Wayne County, Illinois.