30 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Fairfield | 1 | 4,741 | 4,887 | -0.5% | 1,157 | 4 | City |
| Grover | 2 | 3,531 | 3,586 | 0.23% | 180 | 20 | Township |
| Jasper | 3 | 1,739 | 1,746 | 0.4% | 52 | 33 | Township |
| Big Mound | 4 | 1,730 | 1,749 | 0.23% | 33 | 52 | Township |
| Orel | 5 | 1,350 | 1,353 | 0.37% | 29 | 47 | Township |
| Lamard | 6 | 1,339 | 1,342 | 0.37% | 39 | 34 | Township |
| Bedford | 7 | 996 | 1,002 | 0.4% | 29 | 34 | Township |
| Wayne City | 8 | 986 | 1,004 | -0.3% | 570 | 2 | Village |
| Indian Prairie | 9 | 673 | 683 | 0.15% | 18 | 37 | Township |
| Barnhill | 10 | 635 | 627 | 0.79% | 19 | 34 | Township |
| Orchard | 11 | 626 | 631 | 0.48% | 17 | 37 | Township |
| Cisne | 12 | 619 | 628 | -0.16% | 983 | 1 | Village |
| Four Mile | 13 | 558 | 559 | 0.54% | 14 | 40 | Township |
| Leech | 14 | 446 | 451 | 0.22% | 8 | 53 | Township |
| Hickory Hill | 15 | 378 | 379 | 0.53% | 9 | 43 | Township |
| Keith | 16 | 377 | 383 | 0.27% | 10 | 36 | Township |
| Fairfield | 17 | 353 | 368 | -0.84% | 10 | 36 | Township |
| Jeffersonville | 18 | 347 | 355 | -0.29% | 343 | 1 | Village |
| Berry | 19 | 337 | 346 | -0.3% | 9 | 38 | Township |
| Mount Erie | 20 | 332 | 335 | 0.3% | 6 | 53 | Township |
| Arrington | 21 | 314 | 314 | 0.32% | 18 | 17 | Township |
| Elm River | 22 | 244 | 245 | 0.41% | 7 | 36 | Township |
| Sims | 23 | 168 | 170 | 0% | 142 | 1 | Village |
| Garden Hill | 24 | 156 | 165 | -1.27% | 8 | 19 | Township |
| Massilon | 25 | 152 | 144 | 2.01% | 5 | 33 | Township |
| Zif | 26 | 121 | 121 | 0.83% | 7 | 17 | Township |
| Mount Erie | 27 | 94 | 97 | 0% | 245 | 0 | Village |
| Johnsonville | 28 | 70 | 72 | 0% | 329 | 0 | Village |
| Golden Gate | 29 | 61 | 63 | 0% | 772 | 0 | Village |
| Keenes | 30 | 49 | 48 | 0% | 377 | 0 | Village |
Fairfield is the largest city in Wayne County, with a population of 4,741.
Keenes is the smallest city in Wayne County, with a population of 49.
There are 30 cities in Wayne County, Illinois.