7 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Jenkins | 1 | 1,722 | 1,894 | -1.99% | 195 | 9 | City |
| Whitesburg | 2 | 1,590 | 1,765 | -2.15% | 508 | 3 | City |
| Millstone | 3 | 814 | 473 | 5.99% | 3,804 | 0 | CDP |
| McRoberts | 4 | 711 | 790 | -0.7% | 127 | 6 | CDP |
| Fleming-Neon | 5 | 537 | 576 | -1.47% | 333 | 2 | City |
| Mayking | 6 | 537 | 513 | 0.56% | 349 | 2 | CDP |
| Payne Gap | 7 | 205 | 588 | -4.21% | 89 | 2 | CDP |
Jenkins is the largest city in Letcher County, with a population of 1,722.
Payne Gap is the smallest city in Letcher County, with a population of 205.
There are 7 cities in Letcher County, Kentucky.