| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Jenkins | 1 | 1,699 | 1,896 | -1.96% | 192 | 9 | City |
| Whitesburg | 2 | 1,575 | 1,767 | -2.11% | 503 | 3 | City |
| Fleming-Neon | 3 | 529 | 574 | -1.49% | 328 | 2 | City |
Jenkins is the largest city in Letcher County, with a population of 1,699.
Fleming-Neon is the smallest city in Letcher County, with a population of 529.
There are 3 cities in Letcher County, Kentucky.