| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Big Stone Gap | 1 | 5,067 | 5,268 | -0.69% | 1,056 | 5 | Town |
| Wise | 2 | 2,829 | 2,969 | -0.84% | 931 | 3 | Town |
| Coeburn | 3 | 1,522 | 1,597 | -0.85% | 781 | 2 | Town |
| Appalachia | 4 | 1,355 | 1,436 | -1.02% | 394 | 3 | Town |
| Pound | 5 | 828 | 873 | -0.96% | 318 | 3 | Town |
| St. Paul | 6 | 824 | 865 | -0.84% | 598 | 1 | Town |
Big Stone Gap is the largest city in Wise County, with a population of 5,067.
St. Paul is the smallest city in Wise County, with a population of 824.
There are 6 cities in Wise County, Virginia.