| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Wytheville | 1 | 8,098 | 8,270 | -0.37% | 559 | 14 | Town |
| Rural Retreat | 2 | 1,516 | 1,543 | -0.33% | 666 | 2 | Town |
Wytheville is the largest city in Wythe County, with a population of 8,098.
Rural Retreat is the smallest city in Wythe County, with a population of 1,516.
There are 2 cities in Wythe County, Virginia.