21 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Waldorf | 1 | 84,408 | 77,711 | 1.33% | 2,329 | 36 | CDP |
| Bensville | 2 | 17,752 | 13,658 | 7.14% | 1,050 | 17 | CDP |
| Rosaryville | 3 | 12,358 | 11,344 | 0.9% | 1,346 | 9 | CDP |
| La Plata | 4 | 11,677 | 10,168 | 2.66% | 1,568 | 7 | Town |
| La Plata | 5 | 11,677 | 10,162 | 2.66% | 1,568 | 7 | Town |
| Bryans Road | 6 | 8,929 | 8,198 | 1.27% | 580 | 15 | CDP |
| Indian Head | 7 | 4,336 | 3,897 | 2.1% | 3,525 | 1 | Town |
| Indian Head | 8 | 4,336 | 3,890 | 2.1% | 3,525 | 1 | Town |
| Golden Beach | 9 | 3,967 | 3,620 | 0.28% | 1,046 | 4 | CDP |
| Croom | 10 | 2,895 | 2,353 | 0.63% | 85 | 34 | CDP |
| Hughesville | 11 | 2,324 | 2,525 | 0.35% | 208 | 11 | CDP |
| Baden | 12 | 1,846 | 1,574 | -0.97% | 67 | 28 | CDP |
| Cobb Island | 13 | 1,331 | 1,119 | 0.83% | 2,126 | 1 | CDP |
| Potomac Heights | 14 | 1,178 | 1,247 | 0.34% | 1,098 | 1 | CDP |
| Cedarville | 15 | 854 | 577 | 1.07% | 64 | 13 | CDP |
| Pomfret | 16 | 823 | 396 | 2.49% | 300 | 3 | CDP |
| Bryantown | 17 | 611 | 464 | -0.49% | 147 | 4 | CDP |
| Benedict | 18 | 118 | 181 | -7.81% | 506 | 0 | CDP |
| Rock Point | 19 | 78 | 63 | -2.5% | 124 | 1 | CDP |
| Port Tobacco Village | 20 | 21 | 21 | 0% | 114 | 0 | Town |
| Port Tobacco Village | 21 | 21 | 21 | 0% | 114 | 0 | Town |
Waldorf is the largest city in Charles County, with a population of 84,408.
Port Tobacco Village is the smallest city in Charles County, with a population of 21.
There are 21 cities in Charles County, Maryland.