| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| La Plata | 1 | 12,425 | 10,211 | 2.37% | 1,557 | 8 | Town |
| Indian Head | 2 | 4,291 | 3,891 | 2.12% | 3,489 | 1 | Town |
| Port Tobacco Village | 3 | 23 | 21 | 0% | 125 | 0 | Town |
La Plata is the largest city in Charles County, with a population of 12,425.
Port Tobacco Village is the smallest city in Charles County, with a population of 23.
There are 3 cities in Charles County, Maryland.