8 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Bruce | 1 | 1,548 | 1,698 | -1.9% | 635 | 2.44 | Town |
| Calhoun City | 2 | 1,451 | 1,528 | -1.02% | 616 | 2.36 | Town |
| Vardaman | 3 | 1,023 | 1,110 | -1.64% | 754 | 1.36 | Town |
| Derma | 4 | 887 | 961 | -1.66% | 501 | 1.77 | Town |
| New Houlka | 5 | 680 | 697 | -0.44% | 554 | 1.23 | Town |
| Pittsboro | 6 | 149 | 161 | -1.32% | 152 | 0.98 | Village |
| Big Creek | 7 | 124 | 134 | -1.59% | 109 | 1.14 | Village |
| Slate Springs | 8 | 95 | 102 | -1.04% | 67 | 1.42 | Village |
Bruce is the largest city in Calhoun County, with a population of 1,548.
Slate Springs is the smallest city in Calhoun County.
There are 8 cities in Calhoun County, Mississippi.