8 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Bruce | 1 | 1,581 | 1,700 | -1.25% | 649 | 2 | Town |
| Calhoun City | 2 | 1,450 | 1,521 | -0.82% | 615 | 2 | Town |
| Vardaman | 3 | 1,047 | 1,110 | -0.95% | 772 | 1 | Town |
| Derma | 4 | 901 | 960 | -1.1% | 509 | 2 | Town |
| New Houlka | 5 | 677 | 697 | -0.44% | 551 | 1 | Town |
| Pittsboro | 6 | 154 | 162 | -0.65% | 157 | 1 | Village |
| Big Creek | 7 | 124 | 132 | -0.8% | 109 | 1 | Village |
| Slate Springs | 8 | 95 | 103 | -1.04% | 67 | 1 | Village |
Bruce is the largest city in Calhoun County, with a population of 1,581.
Slate Springs is the smallest city in Calhoun County, with a population of 95.
There are 8 cities in Calhoun County, Mississippi.