| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Bruce | 1 | 1,587 | 1,702 | -1.31% | 651 | 2 | Town |
| Calhoun City | 2 | 1,444 | 1,529 | -1.03% | 613 | 2 | Town |
| Vardaman | 3 | 1,048 | 1,115 | -1.13% | 772 | 1 | Town |
| Derma | 4 | 904 | 959 | -1.09% | 510 | 2 | Town |
| New Houlka | 5 | 673 | 695 | -0.59% | 548 | 1 | Town |
| Pittsboro | 6 | 153 | 161 | -1.29% | 156 | 1 | Village |
| Big Creek | 7 | 122 | 131 | -1.61% | 107 | 1 | Village |
| Slate Springs | 8 | 98 | 104 | -1.01% | 69 | 1 | Village |
Bruce is the largest city in Calhoun County, with a population of 1,587.
Slate Springs is the smallest city in Calhoun County, with a population of 98.
There are 8 cities in Calhoun County, Mississippi.