| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Charleston | 1 | 1,645 | 1,874 | -2.55% | 1,214 | 1 | City |
| Tutwiler | 2 | 1,444 | 2,473 | -12.43% | 521 | 3 | Town |
| Webb | 3 | 366 | 411 | -2.4% | 867 | 0 | Town |
| Sumner | 4 | 240 | 275 | -2.83% | 436 | 1 | Town |
| Glendora | 5 | 132 | 149 | -2.22% | 917 | 0 | Village |
Charleston is the largest city in Tallahatchie County, with a population of 1,645.
Glendora is the smallest city in Tallahatchie County, with a population of 132.
There are 5 cities in Tallahatchie County, Mississippi.