| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Tupelo | 1 | 38,091 | 37,918 | 0.01% | 592 | 64 | City |
| Saltillo | 2 | 5,066 | 4,947 | 0.12% | 531 | 10 | City |
| Baldwyn | 3 | 3,105 | 3,066 | 0.03% | 268 | 12 | City |
| Verona | 4 | 2,697 | 2,779 | -0.59% | 734 | 4 | City |
| Guntown | 5 | 2,622 | 2,591 | 0.23% | 412 | 6 | Town |
| Shannon | 6 | 1,494 | 1,494 | -0.13% | 369 | 4 | Town |
| Plantersville | 7 | 853 | 865 | -0.35% | 408 | 2 | Town |
Tupelo is the largest city in Lee County, with a population of 38,091.
Plantersville is the smallest city in Lee County, with a population of 853.
There are 7 cities in Lee County, Mississippi.