
Tupelo
- County:
- Lee County
- County Seat:
- Yes
- Area (mi²):
- 64.383
- State:
- Mississippi
Tupelo is a city located in Lee County, Mississippi. Tupelo has a 2025 population of 37,511. It is also the county seat of .Tupelo is currently declining at a rate of -0.22% annually and its population has decreased by -1.08% since the most recent census, which recorded a population of 37,921 in 2020.
The average household income in Tupelo is $91,660 with a poverty rate of 13.83%. The median age in Tupelo is 38.4 years: 36.5 years for males, and 39.4 years for females.