Tupelo
- County:
- Lee County
- County Seat:
- Yes
- Area (mi²):
- 64.383
- State:
- Mississippi
Tupelo is a city located in Lee County, Mississippi. Tupelo has a 2026 population of 37,775. It is also the county seat of Lee County. Tupelo is currently growing at a rate of 0.15% annually but its population has decreased by -0.38% since the most recent census, which recorded a population of 37,918 in 2020.