| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Mayersville | 1 | 460 | 430 | 1.55% | 418 | 1 | Town |
Mayersville is the largest city in Issaquena County, with a population of 460.
Mayersville is the smallest city in Issaquena County, with a population of 460.
There is 1 city in Issaquena County, Mississippi.