Mayersville
- County:
- Issaquena County
- County Seat:
- Yes
- Area (mi²):
- 1.101
- State:
- Mississippi
Mayersville is a town located in Issaquena County, Mississippi. Mayersville has a 2026 population of 464. It is also the county seat of Issaquena County. Mayersville is currently growing at a rate of 5.94% annually and its population has increased by 7.66% since the most recent census, which recorded a population of 431 in 2020.