| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Macon | 1 | 2,405 | 2,562 | -1.11% | 628 | 4 | City |
| Brooksville | 2 | 846 | 913 | -1.4% | 532 | 2 | Town |
| Shuqualak | 3 | 371 | 403 | -1.59% | 329 | 1 | Town |
Macon is the largest city in Noxubee County, with a population of 2,405.
Shuqualak is the smallest city in Noxubee County, with a population of 371.
There are 3 cities in Noxubee County, Mississippi.