| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Belzoni | 1 | 1,684 | 1,889 | -2.04% | 1,653 | 1 | City |
| Isola | 2 | 560 | 633 | -2.27% | 758 | 1 | Town |
| Louise | 3 | 163 | 178 | -1.81% | 921 | 0 | Town |
| Silver City | 4 | 149 | 232 | -9.7% | 247 | 1 | Town |
| Eden | 5 | 134 | 133 | 0% | 283 | 0 | Village |
Belzoni is the largest city in Humphreys County, with a population of 1,684.
Eden is the smallest city in Humphreys County, with a population of 134.
There are 5 cities in Humphreys County, Mississippi.