| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Durant | 1 | 1,905 | 2,204 | -2.71% | 850 | 2 | City |
| Tchula | 2 | 1,654 | 1,662 | -0.3% | 1,175 | 1 | Town |
| Lexington | 3 | 1,353 | 1,588 | -3.01% | 560 | 2 | City |
| Goodman | 4 | 1,213 | 1,253 | -0.49% | 1,476 | 1 | Town |
| Pickens | 5 | 787 | 917 | -2.84% | 616 | 1 | Town |
| Cruger | 6 | 238 | 270 | -2.46% | 247 | 1 | Town |
| West | 7 | 127 | 152 | -3.79% | 228 | 1 | Town |
Durant is the largest city in Holmes County, with a population of 1,905.
West is the smallest city in Holmes County, with a population of 127.
There are 7 cities in Holmes County, Mississippi.