| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Durant | 1 | 1,859 | 2,201 | -2.97% | 830 | 2 | City |
| Tchula | 2 | 1,644 | 1,655 | -0.12% | 1,168 | 1 | Town |
| Lexington | 3 | 1,316 | 1,589 | -3.31% | 544 | 2 | City |
| Goodman | 4 | 1,216 | 1,252 | -0.49% | 1,479 | 1 | Town |
| Pickens | 5 | 770 | 917 | -3.02% | 603 | 1 | Town |
| Cruger | 6 | 231 | 270 | -2.53% | 240 | 1 | Town |
| West | 7 | 125 | 152 | -3.1% | 224 | 1 | Town |
Durant is the largest city in Holmes County, with a population of 1,859.
West is the smallest city in Holmes County, with a population of 125.
There are 7 cities in Holmes County, Mississippi.