Pickens
- County:
- Holmes County
- County Seat:
- No
- Area (mi²):
- 1.277
- State:
- Mississippi
Pickens is a town located in Holmes County, Mississippi. Pickens has a 2026 population of 819. Pickens is currently declining at a rate of -2.5% annually and its population has decreased by -10.69% since the most recent census, which recorded a population of 917 in 2020.