Lexington
- County:
- Holmes County
- County Seat:
- Yes
- Area (mi²):
- 2.417
- State:
- Mississippi
Lexington is a city located in Holmes County, Mississippi. Lexington has a 2026 population of 1,407. It is also the county seat of Holmes County. Lexington is currently declining at a rate of -2.9% annually and its population has decreased by -11.45% since the most recent census, which recorded a population of 1,589 in 2020.