| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Clarksdale | 1 | 13,403 | 14,773 | -1.76% | 713 | 19 | City |
| Jonestown | 2 | 885 | 960 | -1.56% | 2,287 | 0 | Town |
| Friars Point | 3 | 817 | 892 | -1.57% | 743 | 1 | Town |
| Lyon | 4 | 262 | 291 | -1.87% | 544 | 0 | Town |
| Coahoma | 5 | 209 | 229 | -1.88% | 1,066 | 0 | Town |
| Lula | 6 | 185 | 203 | -2.12% | 444 | 0 | Town |
Clarksdale is the largest city in Coahoma County, with a population of 13,403.
Lula is the smallest city in Coahoma County, with a population of 185.
There are 6 cities in Coahoma County, Mississippi.