Clarksdale
- County:
- Coahoma County
- County Seat:
- Yes
- Area (mi²):
- 18.793
- State:
- Mississippi
Clarksdale is a city located in Coahoma County, Mississippi. Clarksdale has a 2026 population of 13,861. It is also the county seat of Coahoma County. Clarksdale is currently declining at a rate of -0.94% annually and its population has decreased by -6.2% since the most recent census, which recorded a population of 14,777 in 2020.