| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Greenwood | 1 | 13,180 | 14,641 | -1.85% | 1,069 | 12 | City |
| Itta Bena | 2 | 1,443 | 1,671 | -2.63% | 1,023 | 1 | City |
| Schlater | 3 | 213 | 236 | -1.84% | 185 | 1 | Town |
| Morgan City | 4 | 183 | 207 | -2.14% | 312 | 1 | Town |
Greenwood is the largest city in Leflore County, with a population of 13,180.
Morgan City is the smallest city in Leflore County, with a population of 183.
There are 4 cities in Leflore County, Mississippi.