| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Booneville | 1 | 9,291 | 9,154 | 0.37% | 361 | 26 | City |
| Jumpertown | 2 | 436 | 434 | 0% | 244 | 2 | Town |
| Marietta | 3 | 197 | 198 | 0% | 111 | 2 | Town |
| Paden | 4 | 103 | 105 | -0.96% | 114 | 1 | Village |
Booneville is the largest city in Prentiss County, with a population of 9,291.
Paden is the smallest city in Prentiss County, with a population of 103.
There are 4 cities in Prentiss County, Mississippi.