| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Leakesville | 1 | 3,721 | 3,784 | -0.29% | 592 | 6 | Town |
| State Line | 2 | 472 | 452 | 0.64% | 111 | 4 | Town |
Leakesville is the largest city in Greene County, with a population of 3,721.
State Line is the smallest city in Greene County, with a population of 472.
There are 2 cities in Greene County, Mississippi.