| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Southaven | 1 | 58,551 | 54,848 | 1.27% | 1,417 | 41 | City |
| Olive Branch | 2 | 47,819 | 46,569 | 0.54% | 852 | 56 | City |
| Horn Lake | 3 | 26,738 | 26,731 | -0.01% | 1,669 | 16 | City |
| Hernando | 4 | 19,165 | 17,272 | 1.81% | 749 | 26 | City |
| Walls | 5 | 1,437 | 1,348 | 1.2% | 121 | 12 | Town |
Southaven is the largest city in DeSoto County, with a population of 58,551.
Walls is the smallest city in DeSoto County, with a population of 1,437.
There are 5 cities in DeSoto County, Mississippi.