Hernando
- County:
- DeSoto County
- County Seat:
- Yes
- Area (mi²):
- 25.59
- State:
- Mississippi
Hernando is a city located in DeSoto County, Mississippi. Hernando has a 2026 population of 18,542. It is also the county seat of DeSoto County. Hernando is currently growing at a rate of 1.1% annually and its population has increased by 7.33% since the most recent census, which recorded a population of 17,276 in 2020.