Horn Lake
- County:
- DeSoto County
- County Seat:
- No
- Area (mi²):
- 16.025
- State:
- Mississippi
Horn Lake is a city located in DeSoto County, Mississippi. Horn Lake has a 2026 population of 26,574. Horn Lake is currently growing at a rate of 0.02% annually but its population has decreased by -0.62% since the most recent census, which recorded a population of 26,741 in 2020.