
DeSoto County
- State:
- Mississippi
- County Seat:
- Hernando
DeSoto County's estimated 2025 population is 197,453 with a growth rate of 1.08% in the past year according to the most recent United States census data. DeSoto County is the 3rd largest county in Mississippi. The 2010 population was 161,797 and has seen a growth of 22.04% since that time.