Pittsboro
- County:
- Calhoun County
- County Seat:
- Yes
- Area (mi²):
- 0.981
- State:
- Mississippi
Pittsboro is a village located in Calhoun County, Mississippi. Pittsboro has a 2026 population of 157. It is also the county seat of Calhoun County. Pittsboro is currently declining at a rate of -0.63% annually and its population has decreased by -3.09% since the most recent census, which recorded a population of 162 in 2020.