5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Quitman | 1 | 1,922 | 2,052 | -1.33% | 371 | 5 | City |
| Stonewall | 2 | 832 | 875 | -1.07% | 313 | 3 | Town |
| Enterprise | 3 | 473 | 501 | -1.25% | 193 | 2 | Town |
| Shubuta | 4 | 389 | 406 | -1.02% | 161 | 2 | Town |
| Pachuta | 5 | 195 | 205 | -1.02% | 80 | 2 | Town |
Quitman is the largest city in Clarke County, with a population of 1,922.
Pachuta is the smallest city in Clarke County, with a population of 195.
There are 5 cities in Clarke County, Mississippi.