6 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Clarksdale | 1 | 13,403 | 14,777 | -1.68% | 713 | 19 | City |
| Jonestown | 2 | 879 | 960 | -1.46% | 2,271 | 0 | Town |
| Friars Point | 3 | 823 | 894 | -1.44% | 748 | 1 | Town |
| Lyon | 4 | 261 | 291 | -1.88% | 541 | 0 | Town |
| Coahoma | 5 | 212 | 230 | -1.4% | 1,082 | 0 | Town |
| Lula | 6 | 184 | 204 | -1.6% | 441 | 0 | Town |
Clarksdale is the largest city in Coahoma County, with a population of 13,403.
Lula is the smallest city in Coahoma County, with a population of 184.
There are 6 cities in Coahoma County, Mississippi.