14 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Clarksdale | 1 | 13,632 | 14,896 | -1.65% | 725 | 19 | City |
| Clarksdale | 2 | 13,632 | 14,777 | -1.65% | 725 | 19 | City |
| Jonestown | 3 | 892 | 967 | -1.55% | 2,305 | 0 | Town |
| Jonestown | 4 | 892 | 960 | -1.55% | 2,305 | 0 | Town |
| Friars Point | 5 | 835 | 901 | -1.42% | 759 | 1 | Town |
| Friars Point | 6 | 835 | 894 | -1.42% | 759 | 1 | Town |
| Farrell | 7 | 277 | 292 | 1.47% | 213 | 1 | CDP |
| Rena Lara | 8 | 271 | 181 | 7.11% | 118 | 2 | CDP |
| Lyon | 9 | 266 | 293 | -1.85% | 552 | 0 | Town |
| Lyon | 10 | 266 | 291 | -1.85% | 552 | 0 | Town |
| Coahoma | 11 | 215 | 232 | -1.38% | 1,097 | 0 | Town |
| Coahoma | 12 | 215 | 230 | -1.38% | 1,097 | 0 | Town |
| Lula | 13 | 187 | 206 | -2.09% | 448 | 0 | Town |
| Lula | 14 | 187 | 204 | -2.09% | 448 | 0 | Town |
Clarksdale is the largest city in Coahoma County, with a population of 13,632.
Lula is the smallest city in Coahoma County, with a population of 187.
There are 14 cities in Coahoma County, Mississippi.