6 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Clarksdale | 1 | 13,632 | 14,777 | -1.65% | 725 | 19 | City |
| Jonestown | 2 | 892 | 960 | -1.55% | 2,305 | 0 | Town |
| Friars Point | 3 | 835 | 894 | -1.42% | 759 | 1 | Town |
| Lyon | 4 | 266 | 291 | -1.85% | 552 | 0 | Town |
| Coahoma | 5 | 215 | 230 | -1.38% | 1,097 | 0 | Town |
| Lula | 6 | 187 | 204 | -2.09% | 448 | 0 | Town |
Clarksdale is the largest city in Coahoma County, with a population of 13,632.
Lula is the smallest city in Coahoma County, with a population of 187.
There are 6 cities in Coahoma County, Mississippi.