5 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Southaven | 1 | 58,816 | 54,847 | 1.14% | 1,423 | 41 | City |
| Olive Branch | 2 | 47,766 | 46,562 | 0.42% | 851 | 56 | City |
| Horn Lake | 3 | 26,490 | 26,741 | -0.16% | 1,653 | 16 | City |
| Hernando | 4 | 19,175 | 17,276 | 1.68% | 749 | 26 | City |
| Walls | 5 | 1,444 | 1,348 | 1.12% | 122 | 12 | Town |
Southaven is the largest city in DeSoto County, with a population of 58,816.
Walls is the smallest city in DeSoto County, with a population of 1,444.
There are 5 cities in DeSoto County, Mississippi.