5 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Southaven | 1 | 58,154 | 54,847 | 1.15% | 1,407 | 41 | City |
| Olive Branch | 2 | 47,565 | 46,562 | 0.42% | 848 | 56 | City |
| Horn Lake | 3 | 26,532 | 26,741 | -0.16% | 1,656 | 16 | City |
| Hernando | 4 | 18,858 | 17,276 | 1.7% | 737 | 26 | City |
| Walls | 5 | 1,428 | 1,348 | 1.13% | 121 | 12 | Town |
Southaven is the largest city in DeSoto County, with a population of 58,154.
Walls is the smallest city in DeSoto County, with a population of 1,428.
There are 5 cities in DeSoto County, Mississippi.