2 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Leakesville | 1 | 3,758 | 3,780 | -0.11% | 598 | 6.28 | Town |
| State Line | 2 | 465 | 454 | 0.43% | 109 | 4.26 | Town |
Leakesville is the largest city in Greene County, with a population of 3,758.
State Line is the smallest city in Greene County.
There are 2 cities in Greene County, Mississippi.