7 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Tupelo | 1 | 37,703 | 37,918 | -0.1% | 586 | 64 | City |
| Saltillo | 2 | 4,976 | 4,951 | 0.08% | 522 | 10 | City |
| Baldwyn | 3 | 3,090 | 3,071 | 0.1% | 267 | 12 | City |
| Verona | 4 | 2,681 | 2,791 | -0.67% | 730 | 4 | City |
| Guntown | 5 | 2,616 | 2,586 | 0.19% | 411 | 6 | Town |
| Shannon | 6 | 1,490 | 1,493 | 0% | 368 | 4 | Town |
| Plantersville | 7 | 836 | 866 | -0.59% | 399 | 2 | Town |
Tupelo is the largest city in Lee County, with a population of 37,703.
Plantersville is the smallest city in Lee County, with a population of 836.
There are 7 cities in Lee County, Mississippi.