6 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Booneville | 1 | 9,069 | 9,098 | -0.07% | 352 | 25.75 | City |
| Wheeler | 2 | 656 | 407 | 7.19% | 337 | 1.95 | CDP |
| Jumpertown | 3 | 428 | 423 | 0.23% | 239 | 1.79 | Town |
| New Site | 4 | 200 | 134 | 6.95% | 78 | 2.58 | CDP |
| Marietta | 5 | 195 | 194 | 0% | 110 | 1.78 | Town |
| Paden | 6 | 100 | 105 | -0.99% | 111 | 0.90 | Village |
Booneville is the largest city in Prentiss County, with a population of 9,069.
Paden is the smallest city in Prentiss County.
There are 6 cities in Prentiss County, Mississippi.