10 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Booneville | 1 | 9,415 | 9,193 | 0.51% | 366 | 26 | City |
| Booneville | 2 | 9,415 | 9,174 | 0.51% | 366 | 26 | City |
| Wheeler | 3 | 656 | 407 | 7.19% | 337 | 2 | CDP |
| Jumpertown | 4 | 430 | 424 | 0.23% | 240 | 2 | Town |
| Jumpertown | 5 | 430 | 423 | 0.23% | 240 | 2 | Town |
| New Site | 6 | 200 | 134 | 6.95% | 78 | 3 | CDP |
| Marietta | 7 | 193 | 193 | 0% | 108 | 2 | Town |
| Marietta | 8 | 193 | 193 | 0% | 108 | 2 | Town |
| Paden | 9 | 104 | 106 | -0.95% | 116 | 1 | Village |
| Paden | 10 | 104 | 106 | -0.95% | 116 | 1 | Village |
Booneville is the largest city in Prentiss County, with a population of 9,415.
Paden is the smallest city in Prentiss County, with a population of 104.
There are 10 cities in Prentiss County, Mississippi.