5 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Charleston | 1 | 1,609 | 1,869 | -2.6% | 1,187 | 1 | City |
| Tutwiler | 2 | 1,215 | 2,474 | -14.74% | 439 | 3 | Town |
| Webb | 3 | 360 | 410 | -2.17% | 853 | 0 | Town |
| Sumner | 4 | 236 | 275 | -2.48% | 429 | 1 | Town |
| Glendora | 5 | 134 | 149 | -1.47% | 931 | 0 | Village |
Charleston is the largest city in Tallahatchie County, with a population of 1,609.
Glendora is the smallest city in Tallahatchie County, with a population of 134.
There are 5 cities in Tallahatchie County, Mississippi.