10 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Iuka | 1 | 3,057 | 3,148 | -0.59% | 315 | 10 | City |
| Iuka | 2 | 3,057 | 3,146 | -0.59% | 315 | 10 | City |
| Belmont | 3 | 1,806 | 1,862 | -0.61% | 382 | 5 | Town |
| Belmont | 4 | 1,806 | 1,860 | -0.61% | 382 | 5 | Town |
| Burnsville | 5 | 842 | 862 | -0.47% | 176 | 5 | Town |
| Burnsville | 6 | 842 | 861 | -0.47% | 176 | 5 | Town |
| Tishomingo | 7 | 362 | 372 | -0.55% | 424 | 1 | Town |
| Tishomingo | 8 | 362 | 372 | -0.55% | 424 | 1 | Town |
| Dennis | 9 | 26 | 64 | 8.33% | 19 | 1 | CDP |
| Childers Hill | 10 | 25 | 155 | 8.7% | 21 | 1 | CDP |
Iuka is the largest city in Tishomingo County, with a population of 3,057.
Childers Hill is the smallest city in Tishomingo County, with a population of 25.
There are 10 cities in Tishomingo County, Mississippi.