19 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Cape Girardeau | 1 | 41,334 | 39,786 | 0.63% | 1,412 | 29 | City |
| Jackson | 2 | 16,167 | 15,453 | 0.74% | 1,504 | 11 | City |
| Jackson | 3 | 1,222 | 1,145 | 0.49% | 13 | 97 | Township |
| Jackson | 4 | 1,184 | 1,148 | -0.25% | 16 | 76 | Township |
| Jackson | 5 | 895 | 985 | -1.86% | 12 | 75 | Township |
| Jackson | 6 | 710 | 702 | 0% | 15 | 49 | Township |
| Gordonville | 7 | 633 | 621 | 0.32% | 812 | 1 | Village |
| Jackson | 8 | 557 | 539 | 0.72% | 8 | 70 | Township |
| Delta | 9 | 381 | 375 | 0.26% | 967 | 0 | City |
| Altenburg | 10 | 334 | 342 | -0.3% | 318 | 1 | City |
| Oak Ridge | 11 | 239 | 235 | 0.42% | 404 | 1 | Town |
| Jackson | 12 | 192 | 189 | 0.52% | 3 | 56 | Township |
| Haywood City | 13 | 136 | 133 | 0.74% | 318 | 0 | Village |
| Jackson | 14 | 128 | 138 | -2.29% | 3 | 41 | Township |
| Jackson | 15 | 127 | 126 | 0% | 4 | 30 | Township |
| Pocahontas | 16 | 98 | 94 | 1.03% | 951 | 0 | Town |
| Allenville | 17 | 95 | 94 | 0% | 613 | 0 | Village |
| Whitewater | 18 | 85 | 84 | 0% | 397 | 0 | Town |
| Old Appleton | 19 | 75 | 74 | 0% | 620 | 0 | Town |
Cape Girardeau is the largest city in Cape Girardeau County, with a population of 41,334.
Old Appleton is the smallest city in Cape Girardeau County, with a population of 75.
There are 19 cities in Cape Girardeau County, Missouri.