10 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Caruthersville | 1 | 4,985 | 5,540 | -1.81% | 966 | 5 | City |
| Hayti | 2 | 2,171 | 2,477 | -2.3% | 946 | 2 | City |
| Steele | 3 | 1,616 | 1,844 | -2.3% | 747 | 2 | City |
| Hayti Heights | 4 | 443 | 509 | -2.42% | 452 | 1 | City |
| Cooter | 5 | 306 | 344 | -1.92% | 1,037 | 0 | City |
| Wardell | 6 | 269 | 308 | -2.18% | 954 | 0 | Town |
| Holland | 7 | 173 | 194 | -1.7% | 1,036 | 0 | Town |
| Pascola | 8 | 78 | 87 | -1.27% | 488 | 0 | Village |
| Homestown | 9 | 66 | 75 | -1.49% | 537 | 0 | City |
| Bragg City | 10 | 58 | 67 | -1.69% | 284 | 0 | Town |
Caruthersville is the largest city in Pemiscot County, with a population of 4,985.
Bragg City is the smallest city in Pemiscot County, with a population of 58.
There are 10 cities in Pemiscot County, Missouri.