2 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Perryville | 1 | 8,552 | 8,560 | -0.02% | 1,048 | 8 | City |
| Frohna | 2 | 246 | 246 | 0% | 272 | 1 | City |
Perryville is the largest city in Perry County, with a population of 8,552.
Frohna is the smallest city in Perry County, with a population of 246.
There are 2 cities in Perry County, Missouri.