12 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Sikeston | 1 | 16,010 | 16,268 | -0.32% | 894 | 18 | City |
| Scott City | 2 | 4,455 | 4,339 | 0.52% | 920 | 5 | City |
| Chaffee | 3 | 3,009 | 3,046 | -0.27% | 1,676 | 2 | City |
| Oran | 4 | 1,206 | 1,201 | 0.08% | 1,145 | 1 | City |
| Benton | 5 | 921 | 868 | 1.1% | 1,448 | 1 | City |
| Morley | 6 | 683 | 635 | 1.34% | 853 | 1 | City |
| Kelso | 7 | 552 | 556 | -0.18% | 1,741 | 0 | Village |
| Benton | 8 | 482 | 476 | 0% | 12 | 42 | Township |
| Benton | 9 | 441 | 441 | 0.23% | 14 | 31 | Township |
| Blodgett | 10 | 206 | 210 | -0.48% | 1,108 | 0 | City |
| Vanduser | 11 | 186 | 180 | 0.54% | 1,453 | 0 | Village |
| Commerce | 12 | 40 | 42 | -2.44% | 116 | 0 | Village |
Sikeston is the largest city in Scott County, with a population of 16,010.
Commerce is the smallest city in Scott County, with a population of 40.
There are 12 cities in Scott County, Missouri.