4 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Piedmont | 1 | 1,862 | 1,895 | -0.37% | 874 | 2 | City |
| Greenville | 2 | 437 | 445 | -0.46% | 647 | 1 | City |
| Williamsville | 3 | 271 | 275 | -0.37% | 839 | 0 | City |
| Mill Spring | 4 | 157 | 159 | -0.63% | 357 | 0 | Village |
Piedmont is the largest city in Wayne County, with a population of 1,862.
Mill Spring is the smallest city in Wayne County, with a population of 157.
There are 4 cities in Wayne County, Missouri.