4 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Piedmont | 1 | 1,856 | 1,895 | -0.32% | 871 | 2 | City |
| Greenville | 2 | 436 | 445 | -0.23% | 646 | 1 | City |
| Williamsville | 3 | 270 | 275 | -0.37% | 836 | 0 | City |
| Mill Spring | 4 | 157 | 159 | 0% | 357 | 0 | Village |
Piedmont is the largest city in Wayne County, with a population of 1,856.
Mill Spring is the smallest city in Wayne County, with a population of 157.
There are 4 cities in Wayne County, Missouri.