11 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Creighton | 1 | 1,094 | 1,149 | -1% | 904 | 1.21 | City |
| Bloomfield | 2 | 929 | 984 | -1.17% | 1,138 | 0.82 | City |
| Crofton | 3 | 761 | 755 | 0.13% | 1,189 | 0.64 | City |
| Wausa | 4 | 570 | 589 | -0.7% | 1,088 | 0.52 | Village |
| Verdigre | 5 | 534 | 549 | -0.56% | 974 | 0.55 | Village |
| Santee | 6 | 425 | 422 | 0.24% | 754 | 0.56 | Village |
| Niobrara | 7 | 360 | 367 | -0.28% | 495 | 0.73 | Village |
| Center | 8 | 72 | 74 | 0% | 686 | 0.10 | Village |
| Winnetoon | 9 | 49 | 51 | 0% | 169 | 0.29 | Village |
| Verdel | 10 | 38 | 40 | 0% | 220 | 0.17 | Village |
| Lindy | 11 | 21 | 19 | 5% | 21 | 1 | CDP |
Creighton is the largest city in Knox County, with a population of 1,094.
Lindy is the smallest city in Knox County.
There are 11 cities in Knox County, Nebraska.